FACULTY

Mauricio Arruda, MD
Director, Electrophysiology Center
UH Harrington Heart & Vascular Institute
Associate Professor
Case Western Reserve University School of Medicine
Dr. Arruda reports no financial relationship with a commercial interest relevant to this activity.

Guilherme Attizzani, MD
Co-Director, Valve & Structural Heart Disease Center
UH Harrington Heart & Vascular Institute
Assistant Professor
Case Western Reserve University School of Medicine
Dr. Attizzani has received consulting fees from Medtronic and Abbott, and the CME Program has determined there is no conflict of interest.

Mir Babar Basir, DO
Senior Staff, Interventional Cardiology
Henry Ford Health System
Dr. Basir has received honoraria and/or consulting fees from Abiomed, Cardiovascular Systems, Cheisi and Zoll, and the CME Program has determined there is no conflict of interest.

Martin Bocks, MD
Director, Pediatric Interventional Cardiology
UH Rainbow Babies & Children’s Hospital
Associate Professor
Case Western Reserve University School of Medicine
Dr. Bocks has received consulting fees from Edwards Lifesciences, and the CME Program has determined there is no conflict of interest. Presentation will include discussion of unlabeled/investigational uses of a commercial product.

Marc Bonaca, MD
Executive Director, Colorado Prevention Center
William R. Hiatt Endowed Chair for Cardiovascular Research
Director of Vascular Research
University of Colorado
Dr. Bonaca has received grant support and/or consulting fees from Amgen, Aralez, AstraZeneca, Bayer, Janssen, Merck, Pfizer and Sanofi, and the CME Program has determined there is no conflict of interest. Presentation will include discussion of unlabeled/investigational uses of a commercial product.

Ivan Cakulev, MD
Electrophysiology Center
UH Harrington Heart & Vascular Institute
Assistant Professor
Case Western Reserve University School of Medicine
Dr. Cakulev reports no financial relationship with a commercial interest relevant to this activity.

Marco Costa, MD, PhD, MBA
President, UH Harrington Heart & Vascular Institute
Chief Innovation Officer, University Hospitals
Professor, Case Western Reserve University School of Medicine
Dr. Costa reports no financial relationship with a commercial interest relevant to this activity.

Farshad Forouzandeh, MD, PhD
Interventional Cardiovascular Center
UH Harrington Heart & Vascular Institute
Assistant Professor
Case Western Reserve University School of Medicine
Dr. Forouzandeh reports no financial relationship with a commercial interest relevant to this activity.

Adrian Hernandez, MD, MHS
Vice Dean for Clinical Research and Professor
Duke University School of Medicine
Faculty Associate Director, Duke Clinical Research Institute
Dr. Hernandez has received research support and/or consulting fees from AstraZeneca, Bayer, Merck, Novartis and Luitpold, and the CME Program has determined there is no conflict of interest.

Vikram Kashyap, MD
Chief, Division of Vascular Surgery and Endovascular Therapy
UH Harrington Heart & Vascular Institute
Professor
Case Western Reserve University School of Medicine
Dr. Kashyap reports no financial relationship with a commercial interest relevant to this activity.

Jun Li, MD
Interventional Cardiovascular Center
UH Harrington Heart & Vascular Institute
Assistant Clinical Professor
Case Western Reserve University School of Medicine
Dr. Li has received honoraria from Abbott Vascular and Medtronic, and the CME Program has determined there is no conflict of interest.

Chris Longenecker, MD
Director, Research & Innovation Center
UH Harrington Heart & Vascular Institute
Assistant Professor
Case Western Reserve University School of Medicine
Dr. Longenecker reports no financial relationship with a commercial interest relevant to this activity.

Judith Mackall, MD
Director, Electrophysiology Fellowship Program,
UH Harrington Heart & Vascular Institute
Associate Professor
Case Western Reserve University School of Medicine
Dr. Mackall has received honoraria from Abbott, and the CME Program has determined there is no conflict of interest.

Alan Markowitz, MD
Chief Surgical Officer and Interim Chief
Division of Cardiac Surgery
UH Harrington Heart & Vascular Institute
Professor
Case Western Reserve University School of Medicine
Dr. Markowitz reports no financial relationship with a commercial interest relevant to this activity.

Benjamin Medalion, MD
Director, Mechanical Circulatory Support
Division of Cardiac Surgery
UH Harrington Heart & Vascular Institute
Clinical Associate Professor
Case Western Reserve University School of Medicine
Dr. Medalion reports no financial relationship with a commercial interest relevant to this activity.

Mandeep Mehra, MD
Medical Director, Heart and Vascular Center
Executive Director, Collaborative Center for Advanced Heart Failure
Brigham and Women’s Hospital
Professor, Harvard Medical School
Dr. Mehra has received consulting fees from Abbott, Medtronic, Janssen, Bayer, Portola, Nupulse and Mesoblast, and the CME Program has determined there is no conflict of interest. Presentation will include discussion of unlabeled/investigational uses of a commercial product.

Guilherme Oliveira, MD
Director, Advanced Heart Failure & Transplant Center
UH Harrington Heart & Vascular Institute
Clinical Associate Professor
Case Western Reserve University School of Medicine
Dr. Oliveira has received honoraria from Novartis, Amgen, Abbott and Medtronic, and the CME Program has determined there is no conflict of interest.

Sanjay Rajagopalan, MD
Chief, Division of Cardiovascular Medicine
UH Harrington Heart & Vascular Institute
Director, Case Cardiovascular Research Institute
Professor, Case Western Reserve University School of Medicine
Dr. Rajagopalan has received honoraria for his role as consultant and advisory board member from Janssen, Novo and Takeda, and the CME Program has determined there is no conflict of interest.

Goutham Rao, MD
Chair, Department of Family Medicine and Community Health
UH Cleveland Medical Center
Chief, Division of Family Medicine
UH Rainbow Babies & Children’s Hospital
Clinical Instructor
Case Western Reserve University School of Medicine
Dr. Rao reports no financial relationship with a commercial interest relevant to this activity.

Paul Ridker, MD
Director, Center for Cardiovascular Disease Prevention
Brigham and Women’s Hospital
Eugene Braunwald Professor
Harvard Medical School
Dr. Ridker has received research support from AstraZeneca, Novartis, Pfizer, Kowa and Amgen; is a co-inventor on patients held by the Brigham and Women’s Hospital that have been licensed to Siemens and Astrazeneca; and has been a consultant to Quintiles, Novaris, Corvida, Inflazome, Eisai, Sanofi and Janssen, and the CME Program has determined there is no conflict of interest. Presentation will include discussion of unlabeled/investigational uses of a commercial product.

Monique Robinson, MD, PhD
Advanced Heart Failure & Transplant Center
UH Harrington Heart & Vascular Institute
Clinical Assistant Professor
Case Western Reserve University School of Medicine
Dr. Robinson reports no financial relationship with a commercial interest relevant to this activity.

Aditya Sharma, MD
Director, Anticoagulation Clinic and Medical Optimization Clinic
Assistant Professor, University of Virginia
Dr. Sharma reports no financial relationship with a commercial interest relevant to this activity.

Mehdi Shishehbor, DO, MPH, PhD
Director, Interventional Cardiovascular Center
UH Harrington Heart & Vascular Institute
Professor
Case Western Reserve University School of Medicine
Dr. Shishehbor is on the advisory board of, or has received consulting fees from, Abbott, BioClinica, Boston Scientific, Medtronic, Philips/Spectranetics, Shock-Wave Medical, Terumo, Volcano, LamaMed, and RAM Medical Innovations, and the CME Program has determined there is no conflict of interest. Presentation will include discussion of unlabeled/investigational uses of a commercial product.

Kalyanam Shivkumar, MD, PhD
Director, Cardiac Arrhythmia Center and Electrophysiology Programs
Director and Chief, Interventional Cardiovascular Programs
UCLA Health
Professor, University of California, Los Angeles
Dr. Shivkumar reports no financial relationship with a commercial interest relevant to this activity.

Daniel Simon, MD
President
UH Cleveland Medical Center
Professor
Case Western Reserve University School of Medicine
Dr. Simon has received honoraria from Medtronic, and the CME Program has determined there is no conflict of interest.

Christopher Smith, MD
Vascular Center
UH Harrington Heart & Vascular Institute
Assistant Professor,
Case Western Reserve University School of Medicine
Dr. Smith reports no financial relationship with a commercial interest relevant to this activity.

Christopher Snyder, MD
Chief, Division of Pediatric Cardiology
UH Rainbow Babies & Children’s Hospital
Associate Professor,
Case Western Reserve University School of Medicine
Dr. Snyder reports no financial relationship with a commercial interest relevant to this activity.

Antonio Sotolongo, MD
Clinical Cardiac Electrophysiology Fellow
UH Harrington Heart & Vascular Institute
Dr. Sotolongo reports no financial relationship with a commercial interest relevant to this activity.

Claire Sullivan, MD
Evaluation & Prevention Center
UH Harrington Heart & Vascular Institute
Clinical Assistant Professor
Case Western Reserve University School of Medicine
Dr. Sullivan reports no financial relationship with a commercial interest relevant to this activity.

Guillermo Torre, MD, PhD
Professor of Cardiology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College
Dr. Torre reports no financial relationship with a commercial interest relevant to this activity.

Dev Venugopal, MD
Electrophysiology Center,
UH Harrington Heart & Vascular Institute
Clinical Assistant Professor
Case Western Reserve University School of Medicine
Dr. Venugopal reports no financial relationship with a commercial interest relevant to this activity.

Albert Waldo, MD, PhD (Hon)
Electrophysiology Center
UH Harrington Heart & Vascular Institute
Professor
Case Western Reserve University School of Medicine
Dr. Waldo has received honoraria from Pfizer/Bristol-Myers Squibb, Milestone Pharmaceuticals and Cardiac Insight, and the CME Program has determined there is no conflict of interest.

Michael Zacharias, DO
Advanced Heart Failure & Transplant Center
UH Harrington Heart & Vascular Institute
Assistant Professor
Case Western Reserve University School of Medicine
Dr. Zacharias reports no financial relationship with a commercial interest relevant to this activity.

 
David Zidar, MD, PhD
Interventional Cardiovascular Center
UH Harrington Heart & Vascular Institute
Assistant Professor
Case Western Reserve University School of Medicine
Dr. Zidar has received research support from AstraZeneca and honoraria from Medtronic, and the CME Program has determined there is no conflict of interest.

PLANNING COMMITTEE

Marco Costa, MD, PhD, MBA

Dr. Costa reports no financial relationship with a commercial interest relevant to this activity.

Sanjay Rajagopalan, MD

Dr. Rajagopalan has received honoraria for his role as consultant and advisory board member from Janssen, Novo and Takeda, and the CME Program has determined there is no conflict of interest.

Guilherme Attizzani, MD

Dr. Attizzani has received consulting fees from Medtronic and Abbott, and the CME Program has determined there is no conflict of interest.

Guilherme Oliveira, MD

Dr.Oliveira has received honoraria from Novartis, Amgen, Abbott and Medtronic, and the CME Program has determined there is no conflict of interest.

Mehdi Shishehbor, DO, MPH, PhD

Dr. Shishehbor is on the advisory board of, or has received consulting fees from Abbott, BioClinica, Boston Scientific, Medtronic, Philips/Spectranetics, Shock-Wave Medical, Terumo,Volcano, LamaMed and RAM Medical Innovations, and the CME Program has determined there is no conflict of interest. Presentation will include discussion of unlabeled/investigational uses of a commercial product.

ACKNOWLEDGMENTS

Educational grants from Abbott/St. Jude, Abiomed, Biosense Webster, Boston Scientific Corporation and Medtronic are gratefully acknowledged.

Media: Recorded slides and audio presentation.  Supplementary educational materials may include downloads of videos, print materials, slides or web pages.

Target Audience: This program is intended to update practicing internists, family medicine physicians, primary care physicians, cardiologists, cardiac surgeons, vascular surgeons, physician assistants, nurse practitioners, nurses, residents and fellows on current topics in cardiovascular disease.

LEARNING OBJECTIVES

After participating in this activity, participants will be able to:

• Examine the impact of emerging treatment approaches in complex patients with structural heart disease, arrhythmias, heart failure and vascular disease
• Assess the latest diagnostic approaches to help guide treatment
• Discuss the latest information in preventive cardiology

• Utilize guideline and evidence-based strategies to lower risk

ACCREDITATION STATEMENT

Case Western Reserve University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Case Western Reserve University School of Medicine designates this enduring material for a maximum of 6.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Track One: 1.5 Credits

Track Two: 1.25 Credits

Track Three: 1.5 Credits

Track Four: 1.25 Credits

Track Five: 1.25 Credits

Disclosure Statement
The policy of Case Western Reserve University School of Medicine CME Program (CWRU CME) requires that the Activity Director, planning committee members and all activity faculty (that is, anyone in a position to control the content of the education activity) disclose to the activity participants all relevant financial relationships with commercial interests. Where disclosures have been made, conflicts of interest, real or apparent, must be resolved. Disclosure will be made to activity participants prior to the commencement of the activity. CWRU CME also requires that faculty make clinical recommendations based on the best available scientific evidence and that faculty identify any discussion of "off-label" or investigational use of pharmaceutical products or medical devices.

Instructions

To receive statements of credit for up to 6.75 AMA PRA Category 1 Credits™ you must:

1. Review the full content of the recorded sessions.
2. Review any supplementary materials referenced under Resources.
3. Reflect on the content.
4. Successfully complete the post-test. A score of 75% is required for passage.
5. Complete the evaluation.

Your credits will be recorded by the CWRU School of Medicine CME Program and made a part of your cumulative transcript.

Fee
There is no fee for this program.

To contact the CME Provider: E-mail Case Western Reserve University School of Medicine CME at medcme@case.edu

MEDICAL DISCLAIMER

Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The author has checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication.

Although every effort is made to ensure that this material is accurate and up-to-date, it is provided for the convenience of the user and should not be considered definitive. Neither the author nor the Case School of Medicine nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information.

Learners are encouraged to confirm the information contained herein with other sources. This information should not be construed as personal medical advice and is not intended to replace medical advice offered by physicians. The Case School of Medicine will not be liable for any direct, indirect, consequential, special, exemplary, or other damages arising here from.

RESOURCES

CANTOS Trial: N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27. https://www.nejm.org/doi/10.1056/NEJMoa1707914

SCOT-HEART Trial: N Engl J Med. 2018 Sep 6;379(10):924-933. doi: 10.1056/NEJMoa1805971. Epub 2018 Aug 25. https://www.nejm.org/doi/full/10.1056/NEJMoa1805971

American Heart Association Life’s Simple 7 prevention resources: http://www.heart.org/en/healthy-living/healthy-lifestyle/my-life-check--lifes-simple-7

Stone GW, et al. N Engl J Med. 2018 Sep 23. doi: 10.1056/NEJMoa180664 

Reardon MJ, et al. N Engl J Med. 2017 Apr 6;376(14):1321-1331

Kenny D., Hijazi Z.M., Kar S., et al: Percutaneous implantation of the Edwards SAPIEN transcatheter heart valve for conduit failure in the pulmonary position: early phase 1 results from an international multicenter clinical trial. J Am Coll Cardiol 2011; 58: pp. 2248-2256

Cheatham J.P., Hellenbrand W.E., Zahn E.M., et al: Clinical and hemodynamic outcomes up to 7 years after transcatheter pulmonary valve replacement in the US melody valve investigational device exemption trial. Circulation 2015; 131: pp. 1960-1970

Boe BA, Rectenwald JE, Bocks ML. Severely regurgitant left ventricle to ascending aorta conduit in a failing fontan patient treated with a vascular endograft and melody transcatheter pulmonary valve via hybrid approach. Catheter Cardiovasc Interv. 2016 May 17. doi: 10.1002/ccd.26578. [Epub ahead of print] PubMed PMID: 27184689